Tuesday, 31 July 2012

Xeroderma Pigmentosum, the strongest evidence against evolution?

There is a terrible genetic disease called Xeroderma Pigmentosum, or XP. Feel free to Google it. At the heart of the condition is a mutation that damages a system that repairs mutations. The outcome is multiple skin cancers, accelerated ageing, and death by the age of 20 for most sufferers. Terrible.

The condition tells us something about the mechanism for the development of the variations which supposedly led to evolutionary progress. It doesn't work.

DNA is unstable, various environmental insults damage it. However, there are sophisticated mechanisms that repair it. In XP they malfunction, leading to death. The questions for evolutionists, should they dare to attempt to answer it, is how did this mechanism arise in the first place? It cannot have preceded the DNA that codes for it.

Here's an extract from a science paper
 ã1998 by Cell Press

Kaoru Sugasawa,*k Jessica M. Y. Ng,*
Chikahide Masutani,Shigenori Iwai,§
Peter J. van der Spek,*# Andre´ P. M. Eker,*
Fumio Hanaoka,†‡ Dirk Bootsma,*
and Jan H. J. Hoeijmakers*

The biological consequences of mutations and persisting lesions range from the onset of carcinogenesis, genetic disorders, and apoptosis to general  cell malfunctioning that may contribute to aging. To cope with these problems, an elaborate cellular defense has arisen early in evolution, encompassing sophisticated complementary repair pathways and cell cycle checkpoints. Nucleotide excision repair (NER) is one of the most versatile and best studied DNA repair which eliminates a wide varietyof DNA damage.....'

Japan (Friedberg et al., 1995).


Now that IS interesting. The researchers state as an axiom that random mutations are harmful. They cause cancer, cell death and premature ageing. Bad news for evolution, since random mutations are the only available mechanism it has to build new features and new creatures for natural selection to choose between. Plenty of evidence though that mutations big enough to confer a selectable difference are harmful. But thankfully 'an elaborate cell defence mechanism' exists which repairs most of the damage. Good for the organism, bad for evolution theory.

So how did these  'sophisticated complementary repair pathways and cell cycle checkpoints' evolve?

Simple. They just did. They arose, just like life itself according to evolutionists. 'There is no salvation to those who deny this doctrine'

This is the sort of bold assertion that passes for evidence in the alternative reality world of Darwinian dreaming.

The heart of any decent person goes out to the young sufferers from this appalling genetic disorder. But the question must be asked. Since XP is such strong evidence for the harmful nature of mutations, both as a mutation itself and from what it teaches us about the need for a mutation-stopping mechanism, why is it not cited in schools to balance the very weak example of beneficial mutation provided by sickle cell disease? Could this be anything to do with confirmation bias and careful selection of evidence by evolutionists?

Molecular Cell, Vol. 2, 223–232, August, 1998, Copyright

Xeroderma Pigmentosum Group C Protein Complex is the Initiator of Global Genome
Nucleotide Excision Repair


  1. My daughter has XP. You can read about her at http://www.AnnaLiberty.wordpress.com

    I know that God lives and created us in His image. I don't know all the ways God's creations were accomplished and how evolution might have been a tool is some way.

    But I know that through the power of Christ's resurrection my daughter will be healed one day.

  2. Dear Tennor

    I am sorry that your daughter has this disease. When I use XP as an example of how mutations wreak havoc with DNA, I do think about the suffering of the children who have it and of their loved ones. I don't mean to cause offence, my primary goal in what I post is to help men and women, if possible, to turn to Christ.

    brotherly regards. Elwin Daniels

  3. Thanx for Sharing knowledge about Cause, Symptoms and Treatment Xeroderma Pigmentosum


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